Kinder M, Greenplate AR, Strohl WR, Jordan RE, Brezski RJ (2015) An Fc engineering approach that modulates antibody-dependent cytokine release without altering cell-killing functions. mAbs 7:494–504. https://doi.org/10.1080/19420862.2015.1022692 Noy R, Pollard JW (2014) Tumor-associated macrophages: from mechanisms to therapy. Immunity 41:49–61. https://doi.org/10.1016/j.immuni.2014.06.010 HuT78/PD-1 cells were labeled with carboxyfluorescein succinimidyl ester (CFSE) (Life technologies) according to the manufacturer’s instructions. M2 macrophages were detached by Accutase™ and plated in V-bottom 96-well plates with CFSE-labeled HuT78/PD-1 at a ratio of 2:1 (HuT78/PD-1 cell to macrophage) in the presence of PD-1 mAbs for 5 h at 37 °C. After co-culturing, cells were stained with anti-CD11b-APC and subjected to flow cytometry. The percentage of macrophages that underwent ADCP of HuT78/PD-1 was determined by FACS of double positive cells (CFSE + and CD11b +) following gating on CD11b + M2 macrophages. FACS analysis An open‐label, multicohort study to investigate the preliminary antitumor activity, safety, and PK of the anti–PD‐1 monoclonal antibody tislelizumab (BGB‐A317) in combination with chemotherapy as first‐line treatment in Chinese subjects with locally advanced or metastatic lung cancer In this test we use 100% on the CPU cores, monitoring their frequencies and chip temperature. The first column shows a computer’s reaction to a short load (2-10 seconds), the second column simulates a serious task (between 15 and 30 seconds), and the third column is a good indicator of how good the laptop is for long loads such as video rendering.

An open‐label, multicenter study to investigate the efficacy, safety, and PK of the anti–PD‐1 monoclonal antibody tislelizumab (BGB‐A317) in patients with previously treated hepatocellular unresectable carcinoma An open‐label, multicenter, randomized study to investigate the efficacy and safety of anti–PD‐1 antibody tislelizumab (BGB‐A317) compared with docetaxel in patients with non‐small cell lung cancer who have progressed on a prior platinum‐containing regimen Tislelizumab is an antiprogrammed cell death protein 1 (PD‐1) antibody with antitumor activity and a tolerable safety profile in patients with various advanced or metastatic cancers.A single‐arm, multicenter phase II study of tislelizumab (BGB‐A317) in patients with previously treated PD‐L1+ locally advanced or metastatic urothelial bladder cancer Keir ME, Butte MJ, Freeman GJ, Sharpe AH (2008) PD-1 and its ligands in tolerance and immunity. Ann Rev Immunol 26:677–704. https://doi.org/10.1146/annurev.immunol.26.021607.090331 Acer Aspire 3 (A317-54)’s IPS panel has a Full HD resolution, comfortable viewing angles, and a good contrast ratio. Furthermore, it doesn’t use PWM for brightness adjustment. However, the 55% sRGB color coverage means that the picture is not really vibrant. Zhang QW, Liu L, Gong CY, Shi HS, Zeng YH, Wang XZ, Zhao YW, Wei YQ (2012) Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature. PloS One 7:e50946. https://doi.org/10.1371/journal.pone.0050946

Installing our Health-Guard profile not only eliminates PWM but also reduces the harmful Blue Light emissions while keeping the colors of the screen perceptually accurate. If you’re not familiar with the Blue light, the TL;DR version is – emissions that negatively affect your eyes, skin, and your whole body. You can find more information about that in our dedicated article on Blue Light. Gloss level measurement Only rivaled by the MSI Modern 15 (B12M), the Acer Aspire 3 (A317-54) beats every other notebook we’ve tested with the Core i7-1255U. Both in terms of short bursts, or long extreme loads. Comfort during full loadStill, we’ve included other color spaces like the famous DCI-P3 standard used by movie studios, as well as the digital UHD Rec.2020 standard. Rec.2020, however, is still a thing of the future and it’s difficult for today’s displays to cover that well. We’ve also included the so-called Michael Pointer gamut, or Pointer’s gamut, which represents the colors that naturally occur around us every day. Labrijn AF, Buijsse AO, van den Bremer ET et al (2009) Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo. Nat Biotechnol 27:767–771. https://doi.org/10.1038/nbt.1553

We also experienced a lot of body flex, both from the lid and from the base. The build quality is not great, with the exception of the dimensions, which are impressive for a 17-incher. In Study BGB‐A317‐001, during phase Ia (Part 1), 22 patients received one of four escalating doses of tislelizumab q2w: 0.5mg/kg ( n=3), 2mg/kg ( n=6), 5mg/kg ( n=6), and 10mg/kg ( n=7). In Part 2, 81 patients received tislelizumab 2mg/kg q2w ( n=20), 5mg/kg q2w ( n=20), 2mg/kg q3w ( n=21), and 5mg/kg q3w ( n=20). In Part 3, 13 patients were treated with fixed‐dose tislelizumab at 200mg q3w. All patients enrolled in phase Ib of the study ( n=335) were treated with tislelizumab 5mg/kg q3w.Sutterwala FS, Noel GJ, Salgame P, Mosser DM (1998) Reversal of proinflammatory responses by ligating the macrophage Fcgamma receptor type I. J Exp Med 188:217–222 Wang C, Thudium KB, Han M et al. (2014) In vitro characterization of the anti-PD-1 antibody nivolumab, BMS-936558, and in vivo toxicology in non-human primates. Cancer Immunol Res 2:846–856. https://doi.org/10.1158/2326-6066.CIR-14-0040