Solgar Choline 250 mg / Inositol 250 mg Vegetable Capsules - Pack of 50 - Supports Metabolising Nutrients - Improves Transport of Fat for a Clear Liver - Vegan and Gluten Free

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Moghetti, P. (2016). "Insulin resistance and polycystic ovary syndrome". Current Pharmaceutical Design. 22 (36): 5526–5534. doi: 10.2174/1381612822666160720155855. PMID 27510482. a b Carlomagno, G.; Unfer, V.; Roseff, S. (2011). "The D- chiro-inositol paradox in the ovary". Fertility and Sterility. 95 (8): 2515–6. doi: 10.1016/j.fertnstert.2011.05.027. PMID 21641593. Sil A, et al. (2018). A randomized, open labeled study comparing the serum levels of cobalamin after three doses of 500 mcg vs. a single dose methylcobalamin of 1500 mcg in patients with peripheral neuropathy.

Laurence, W. L. (April 17, 1936). "Corn by-product yields explosive". The New York Times. p.7. Archived from the original on 2013-05-12. Your body needs inositol for the functioning and development of your cells. While research is still ongoing, people also use inositol for many different health reasons. Inositol benefits may include: Facchinetti, F.; etal. (2015). "Results from the International Consensus Conference on myo-Inositol and D- chiro-Inositol in Obstetrics and Gynecology: the link between metabolic syndrome and PCOS". European Journal of Obstetrics & Gynecology and Reproductive Biology. 195: 72–6. doi: 10.1016/j.ejogrb.2015.09.024. PMID 26479434. Reynolds, J. E. F. (1993). Martindale: The Extra Pharmacopoeia. Vol.30. Pennsylvania: Rittenhouse Book Distributors. p.1379. ISBN 978-0-85369-300-0. An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin has not been identified in man

For polycystic ovary syndrome: 1.2 grams of DCI once daily, or 2 grams of MYO and 200 mcg of folic acid twice daily for 6 months ( 17, 20). Brady, S.; Siegel, G.; Albers, R. W.; Price, D. (2005). Basic Neurochemistry: Molecular, Cellular and Medical Aspects. Academic Press. p.348. ISBN 9780080472072. Thal, L. J., Rosen, W., Sharpless, N. S., and Crystal, H. Choline chloride fails to improve cognition of Alzheimer's disease. Neurobiol.Aging 1981;2(3):205-208. View abstract.

Chuaqui, P. and Levy, R. Fluctuations of free choline levels in plasma of Alzheimer patients receiving lecithin: preliminary observations. Br.J.Psychiatry 1982;140:464-469. View abstract. Besides improving TSH levels (indicating improved TH-synthesis by the thyrocytes), MYO improves thyroid antibody levels, indicating ameliorations of the autoimmune process. HT is characterized by increased levels of Interferon γ (IFN-γ), which stimulates natural killer cells and lymphocytes CD4+ and CD8+ to secrete CXCL10 cytokine. CXCL10 is an important inflammatory marker for the thyroid, since it causes a strong inflammatory response that damages thyroidal morphology and functionality ( 70). https://www.mayoclinic.org/healthy-lifestyle/weight-loss/expert-answers/vitamin-b12-injections/faq-20058145 Neufingerl N, etl al. (2021). Nutrient intake and status in adults consuming plant-based diets compared to meat-eaters: A systematic review.

Myo-Inositol in the Treatment of Subclinical Hypothyroidism

Noteworthy, current practice guidelines, which however produced many controversies, restrict the use of levothyroxine in the SCH to patients with overt hypothyroidism and TSH >10 mIU/mL. Indeed, one of the most critical problems related to SCH management, is the over treatment even in those patients for which it is not necessary. Pharmacological treatment of SCH is recommended only in particular cases, such as women seeking pregnancy and patients with important comorbidities ( 38, 43, 44), and it should be tailored to the individual patient based on the exposure at specific risk factors. Myo-Inositol It depends. People who have a B12 deficiency or need extra folate can benefit from supplementing with single-nutrient products. But other people may benefit from taking a vitamin B complex that covers their needs for all eight B vitamins. What is the best form of B vitamin to take? Active ingredients: thiamine, riboflavin, niacin, vitamin B6, folate, vitamin B12, biotin, pantothenic acid

One six-month study in 80 postmenopausal women with metabolic syndrome found that 4 grams per day of inositol improved insulin sensitivity, blood pressure and cholesterol levels more than a placebo ( 10). a b c d e Kiani AK, Paolacci S, Bertelli M (2021). "From Myo-inositol to D-chiro-inositol molecular pathways". European Review for Medical and Pharmacological Sciences. 25 (5): 2390–2402. doi: 10.26355/eurrev_202103_25279. PMID 33755975. Croze, M. L.; Soulage, C. O. (October 2013). "Potential role and therapeutic interests of myo-inositol in metabolic diseases". Biochimie. 95 (10): 1811–1827. doi: 10.1016/j.biochi.2013.05.011. PMID 23764390. Barbeau, A. Emerging treatments: replacement therapy with choline or lecithin in neurological diseases. Can.J.Neurol.Sci. 1978;5(1):157-160. View abstract.Rapiejko, P. J.; Northup, J. K.; Evans, T.; Brown, J. E.; Malbon, C. C. (November 1986). "G-proteins of fat-cells. Role in hormonal regulation of intracellular inositol 1,4,5-trisphosphate". The Biochemical Journal. 240 (1): 35–40. doi: 10.1042/bj2400035. PMC 1147372. PMID 3103610. Several B vitamins are used by the body during physical activity for energy production, tissue regeneration, and more. This makes it especially important for athletes and anyone active to meet their vitamin B needs through foods or supplements. Despite these long-term risks, the management of SCH still remains highly debated. The standard pharmacological treatment for hypothyroidism is based on levothyroxine (synthetic T4), due to its efficacy, long-term benefits, and good adsorption ( 38). However, some patient subgroups referred a slight preference for the combined therapy based on L-thyroxine and L-triiodothyronine (T3) ( 39), opening still unresolved issues in the management of hypothyroidism. Indeed, common variations in the gene codifying for the deiodinase type 2 may be responsible for both poorer psychological well-being on T4 monotherapy and improved response to combined T4/T3 therapy in patients on thyroid hormone replacement ( 40). On the other hand, studies comparing monotherapy with combined therapy, pointed out that subjects were unable to distinguish treatment and although as many as 18% preferred the combined approach, there was a relatively high incidence of side effects among those using the combination, making the topic more controversial ( 41, 42). In addition, as reported in the international guidelines drawn up by the American Thyroid Association Task Force on Thyroid Hormone Replacement, there is no consistently strong evidence of greater efficacy of the combined therapy over monotherapy with levothyroxine ( 43), confirming the monotherapy as the mainstay of treating hypothyroidism.